Chemical Structure
Inhibitor
1856 Citations
Ibrutinib
BT-0003
Ibrutinib is a potent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). It covalently binds to Cys481 in the ATP-binding pocket of BTK.
Biological Activity
Irreversible BTK inhibitor that blocks B-cell receptor signaling and reduces tumor cell proliferation.
Product Specifications
CAS Number936563-96-1
Molecular FormulaC25H24N6O2
Molecular Weight440.5 g/mol
TargetBTK
PathwayB Cell Receptor Signaling
Disease AreaCancer
IC50/EC50/KdIC50: 0.5 nM (BTK)
Purity>99%
SolubilityDMSO: ≥10 mg/mL
Storage-20°C, desiccated
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 5 mg | $55.00 | |
| 25 mg | $195.00 |