Chemical Structure
Inhibitor
1230 Citations
Tofacitinib
BT-0004
Tofacitinib is a potent JAK3 inhibitor with selectivity over JAK1 and JAK2. It is approved for rheumatoid arthritis and ulcerative colitis treatment.
Biological Activity
Selective JAK3 inhibitor that modulates immune and inflammatory responses by blocking cytokine signaling.
Product Specifications
CAS Number477600-75-2
Molecular FormulaC16H20N6O
Molecular Weight312.37 g/mol
TargetJAK3
PathwayJAK/STAT Signaling
Disease AreaImmunology
IC50/EC50/KdIC50: 1 nM (JAK3), 20 nM (JAK1)
Purity>98%
SolubilityDMSO: ≥50 mg/mL
Storage-20°C
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 5 mg | $40.00 | |
| 50 mg | $250.00 |