Chemical Structure
Inhibitor
New
2100 Citations
Olaparib
BT-0005
Olaparib is a potent PARP1/2 inhibitor approved for BRCA-mutated ovarian and breast cancers. It exploits synthetic lethality in homologous recombination-deficient tumors.
Biological Activity
Traps PARP on DNA and prevents single-strand break repair, leading to double-strand breaks and cell death in HR-deficient cells.
Product Specifications
CAS Number763113-22-0
Molecular FormulaC24H23FN4O3
Molecular Weight434.46 g/mol
TargetPARP1/2
PathwayDNA Damage Response
Disease AreaCancer
IC50/EC50/KdIC50: 5 nM (PARP1), 1 nM (PARP2)
Purity>99%
SolubilityDMSO: ≥20 mg/mL
Storage-20°C, desiccated
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 5 mg | $60.00 | |
| 25 mg | $210.00 | |
| 100 mg | $550.00 |