Chemical Structure
Inhibitor
New
1050 Citations
Osimertinib
BT-0019
Osimertinib is a third-generation, irreversible EGFR inhibitor targeting both EGFR-sensitizing mutations and the T790M resistance mutation in NSCLC.
Biological Activity
Covalently binds Cys797 in the EGFR kinase domain, inhibiting mutant EGFR while sparing wild-type EGFR.
Product Specifications
CAS Number1421373-65-0
Molecular FormulaC28H33N7O2
Molecular Weight499.62 g/mol
TargetEGFR T790M
PathwayEGFR Signaling
Disease AreaCancer
IC50/EC50/KdIC50: 1 nM (EGFR L858R/T790M)
Purity>99%
SolubilityDMSO: ≥20 mg/mL
Storage-20°C, desiccated
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 10 mg | $70.00 | |
| 50 mg | $240.00 |