BRD4 PROTAC Degrader (dBET6)

BT-0021

dBET6 is a potent PROTAC that recruits CRBN E3 ubiquitin ligase to degrade BRD4, a therapeutic target in MYC-driven cancers.

Biological Activity

Induces rapid and selective proteasomal degradation of BRD4 at sub-nanomolar concentrations.

Product Specifications

CAS Number2069948-82-1

Molecular FormulaC45H50N8O8S

Molecular Weight883 g/mol

TargetBRD4

PathwayEpigenetics / BET Bromodomain

Disease AreaCancer

IC50/EC50/KdDC50: <1 nM (BRD4 in Jurkat cells)

Purity>98%

SolubilityDMSO: ≥10 mg/mL

Storage-20°C, desiccated

SpeciesHuman

Available Sizes

Size	Price
1 mg	$185.00
5 mg	$620.00