Chemical Structure
Inhibitor
New
480 Citations
Pevonedistat (MLN4924)
BT-0022
Pevonedistat inhibits the NEDD8-activating enzyme (NAE1), preventing neddylation of cullin-RING ligase complexes and disrupting ubiquitin-mediated protein degradation.
Biological Activity
Causes accumulation of CRL substrates (p27, CDT1, WEE1), leading to DNA re-replication stress and apoptosis.
Product Specifications
CAS Number905579-51-3
Molecular FormulaC21H25FN4O3S
Molecular Weight436.51 g/mol
TargetNEDD8-activating enzyme (NAE)
PathwayUbiquitin-Proteasome
Disease AreaCancer
IC50/EC50/KdIC50: 4.7 nM (NAE1)
Purity>99%
SolubilityDMSO: ≥10 mg/mL
Storage-20°C, desiccated
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 5 mg | $90.00 | |
| 25 mg | $310.00 |