Chemical Structure
Modulator
980 Citations
Lenalidomide
BT-0023
Lenalidomide is an immunomodulatory drug (IMiD) approved for multiple myeloma, MDS, and MCL. Acts as a molecular glue degrader via CRBN.
Biological Activity
Binds CRBN and promotes ubiquitination and degradation of Ikaros (IKZF1) and Aiolos (IKZF3) transcription factors.
Product Specifications
CAS Number191732-72-6
Molecular FormulaC13H13N3O3
Molecular Weight259.26 g/mol
TargetCRBN / CRL4 E3 Ubiquitin Ligase
PathwayUbiquitin-Proteasome
Disease AreaCancer
IC50/EC50/KdIC50: ~100 nM (anti-proliferative, MM cells)
Purity>99%
SolubilityDMSO: ≥50 mg/mL
Storage-20°C
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 10 mg | $35.00 | |
| 100 mg | $120.00 |