Chemical Structure
Inhibitor
310 Citations
GSK-J4
BT-0025
GSK-J4 is a cell-permeable prodrug of GSK-J1, a potent inhibitor of H3K27 histone demethylases KDM6A (UTX) and KDM6B (JMJD3).
Biological Activity
Increases H3K27me3 levels by blocking JMJD3/UTX demethylase activity, suppressing inflammatory and tumor-promoting gene expression.
Product Specifications
CAS Number1373423-53-0
Molecular FormulaC23H25N5O2
Molecular Weight419.48 g/mol
TargetKDM6A/KDM6B (JMJD3/UTX)
PathwayEpigenetics / Histone Demethylation
Disease AreaCancer, Immunology
IC50/EC50/KdIC50: 60 nM (JMJD3/KDM6B)
Purity>98%
SolubilityDMSO: ≥10 mg/mL
Storage-20°C, desiccated
SpeciesHuman
Available Sizes
| Size | Price | |
|---|---|---|
| 5 mg | $95.00 | |
| 25 mg | $330.00 |